GENETIC AND ENVIRONMENTAL CONTRIBUTIONS TO CHOLESTEROL AND ITS SUBFRACTIONS IN 11-YEAR-OLD TWINS - THE MEDICAL-COLLEGE OF VIRGINIA TWIN STUDY

被引：16

作者：

BODURTHA, JN

CHEN, CW

MOSTELLER, M

NANCE, WE

SCHIEKEN, RM

SEGREST, J

机构：

[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,CHILDREN MED CTR,DIV PEDIAT CARDIOL,BOX 26,MCV,RICHMOND,VA 23298

[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT HUMAN GENET,RICHMOND,VA 23298

[3] UNIV ALABAMA,ATHEROSCLEROSIS RES UNIT,BIRMINGHAM,AL 35294

来源：

ARTERIOSCLEROSIS AND THROMBOSIS | 1991年 / 11卷 / 04期

关键词：

CHOLESTEROL; CARDIOVASCULAR RISK; LIPOPROTEIN CHOLESTEROL; GENETICS; TWINS;

D O I：

10.1161/01.ATV.11.4.844

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We conducted a cross-sectional analysis of the genetic and environmental contributions to the variance of lipoprotein cholesterol and its subfractions in children during early adolescence. Univariate path analysis was used to determine the relative contributions of genes, individual environment, and family environment to these measures in 233 11-year-old Caucasian twin pairs. For high density lipoprotein, high density lipoprotein2, low density lipoprotein, very low density lipoprotein, and triglycerides, a model that incorporated genes and individual environmental variation but not common environment was sufficient to explain the variation. Different magnitudes of genetic effects were seen for total cholesterol in boys and girls. High density lipoprotein3 showed different magnitudes by sex for genetic and individual environmental effect. Intermediate density lipoprotein was the only cholesterol subfraction in which shared, or common, environment was found to make a statistically significant contribution to the variation.

引用

页码：844 / 850

页数：7

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