GENETIC AND ENVIRONMENTAL CONTRIBUTIONS TO CHOLESTEROL AND ITS SUBFRACTIONS IN 11-YEAR-OLD TWINS - THE MEDICAL-COLLEGE OF VIRGINIA TWIN STUDY

被引:16
作者
BODURTHA, JN
CHEN, CW
MOSTELLER, M
NANCE, WE
SCHIEKEN, RM
SEGREST, J
机构
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,CHILDREN MED CTR,DIV PEDIAT CARDIOL,BOX 26,MCV,RICHMOND,VA 23298
[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT HUMAN GENET,RICHMOND,VA 23298
[3] UNIV ALABAMA,ATHEROSCLEROSIS RES UNIT,BIRMINGHAM,AL 35294
来源
ARTERIOSCLEROSIS AND THROMBOSIS | 1991年 / 11卷 / 04期
关键词
CHOLESTEROL; CARDIOVASCULAR RISK; LIPOPROTEIN CHOLESTEROL; GENETICS; TWINS;
D O I
10.1161/01.ATV.11.4.844
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We conducted a cross-sectional analysis of the genetic and environmental contributions to the variance of lipoprotein cholesterol and its subfractions in children during early adolescence. Univariate path analysis was used to determine the relative contributions of genes, individual environment, and family environment to these measures in 233 11-year-old Caucasian twin pairs. For high density lipoprotein, high density lipoprotein2, low density lipoprotein, very low density lipoprotein, and triglycerides, a model that incorporated genes and individual environmental variation but not common environment was sufficient to explain the variation. Different magnitudes of genetic effects were seen for total cholesterol in boys and girls. High density lipoprotein3 showed different magnitudes by sex for genetic and individual environmental effect. Intermediate density lipoprotein was the only cholesterol subfraction in which shared, or common, environment was found to make a statistically significant contribution to the variation.
引用
收藏
页码:844 / 850
页数:7
相关论文
共 35 条
[11]   NATURE OF THE FAMILIAL INFLUENCE ON PLASMA-LIPID LEVELS [J].
HEWITT, D ;
JONES, GJL ;
GODIN, GJ ;
WRAIGHT, D ;
BRECKENRIDGE, WC ;
LITTLE, JA ;
STEINER, G ;
MISHKEL, MA .
ATHEROSCLEROSIS, 1979, 32 (04) :381-396
[12]   A DEVELOPMENTAL HYPOTHESIS FOR ADULT-BLOOD PRESSURE [J].
HEWITT, JK ;
CARROLL, D ;
SIMS, J ;
EAVES, LJ .
ACTA GENETICAE MEDICAE ET GEMELLOLOGIAE, 1987, 36 (04) :475-483
[13]  
ISELIUS L, 1979, CLIN GENET, V15, P300
[14]   DISTRIBUTIONS AND FAMILIAL STUDIES OF BLOOD PRESSURE AND SERUM CHOLESTEROL LEVELS IN A TOTAL COMMUNITY - TECUMSEH MICHIGAN [J].
JOHNSON, BC ;
EPSTEIN, FH ;
KJELSBERG, MO .
JOURNAL OF CHRONIC DISEASES, 1965, 18 (02) :147-+
[15]  
Joreskong K.G., 1989, LISREL7 GUIDE PROGRA
[16]   CHOLESTEROL IN THE PREDICTION OF ATHEROSCLEROTIC DISEASE - NEW PERSPECTIVES BASED ON THE FRAMINGHAM STUDY [J].
KANNEL, WB ;
CASTELLI, WP ;
GORDON, T .
ANNALS OF INTERNAL MEDICINE, 1979, 90 (01) :85-91
[17]   INVESTIGATION OF CORONARY HEART-DISEASE IN FAMILIES - FRAMINGHAM OFFSPRING STUDY [J].
KANNEL, WB ;
FEINLEIB, M ;
MCNAMARA, PM ;
GARRISON, RJ ;
CASTELLI, WP .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1979, 110 (03) :281-290
[18]   INHERITANCE OF HIGH-DENSITY-LIPOPROTEIN AND LIPOPROTEIN-LIPASE AND HEPATIC LIPASE ACTIVITY [J].
KUUSI, T ;
KESANIEMI, YA ;
VUORISTO, M ;
MIETTINEN, TA ;
KOSKENVUO, M .
ARTERIOSCLEROSIS, 1987, 7 (04) :421-425
[19]   FAMILY RESEMBLANCE FOR PLASMA-LIPIDS AND LIPOPROTEIN CONCENTRATIONS IN BLACKS - CINCINNATI-LIPID-RESEARCH-CLINIC FAMILY STUDY [J].
LASKARZEWSKI, PM ;
GLUECK, CJ ;
RAO, DC .
ARTERIOSCLEROSIS, 1984, 4 (01) :65-69
[20]   GENETIC-ANALYSIS OF SERUM-LIPID LEVELS AND BLOOD-PRESSURE IN A LARGE KINDRED [J].
MARAZITA, ML ;
ELSTON, RC ;
NAMBOODIRI, KK ;
HAMES, CG .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1987, 26 (03) :511-519