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3 NOVEL MOLECULAR-FORMS OF BILIARY GLYCOPROTEIN DEDUCED FROM CDNA CLONES FROM A HUMAN-LEUKOCYTE LIBRARY
被引:46
作者:
KUROKI, M
ARAKAWA, F
MATSUO, Y
OIKAWA, S
NAKAZATO, H
MATSUOKA, Y
机构:
[1] FUKUOKA UNIV,SCH MED,DEPT BIOCHEM,7-45-1 NANAKUMA,JONAN KU,FUKUOKA 81401,JAPAN
[2] SUNTORY BIOMED INST,OSAKA 618,JAPAN
关键词:
D O I:
10.1016/S0006-291X(05)80223-2
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Three cDNA clones that encode three novel variants of biliary glycoprotein a (BGPa), a glycoprotein belonging to the CEA gene family, were identified in a human leukocyte cDNA library. The domain structures of the predicted proteins of the three clones W211, W233 and W239 are N-A1-B1-A2, N-A1-B1 and N-A1-B1-C, respectively; they lack the transmembrane and cytoplasmic domains that exist in the four BGP species (BGPa, BGPb, BGPc and BGPd) previously reported. Their sequences from N to B1 or to A2 are virtually identical to those of BGPa-d. Comparison with the genomic sequence for BGPa-d suggested that these three new BGP variants as well as BGPa-d are generated from the same single gene by alternative splicing of RNA. © 1991 Academic Press, Inc.
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页码:578 / 585
页数:8
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