BIOLOGICAL EFFECT OF GEOMETRICAL-ISOMERS OF RETINOIC ACID ON HUMAN PROMYELOCYTIC LEUKEMIA (HL-60) CELLS

被引：7

作者：

MURAYAMA, A

SUZUKI, T

MATSUI, M

机构：

[1] Department of Clinical Genetics, The Tokyo Metropolitan Institute of Medical Science, Tokyo, 3-18-22 Honkomagome

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 1994年 / 70卷 / 06期

关键词：

PHOTOISOMERIZATION; ALL-TRANS-RETINOIC ACID; 9-CIS-RETINOIC ACID; 13-CIS-RETINOIC ACID; 9,13-DI-CIS-RETINOIC ACID; HL-60; DIFFERENTIATION;

D O I：

10.2183/pjab.70.81

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Biological activities of geometrical isomers of retinoic acid on human acute promyelocytic leukemia cell line HL-60 were analized by strictly excluding the effects of artificial isomerization. Varying from previous reports, 9-cis-retinoic acid showed over tenfold higher activity than all-trans-retinoic acid. Activity of 13-cis-retinoic acid corresponded roughly to that of all-trans-retinoic acid, and activity of 9,13-di-cis-retinoic acid was approximately 1/10 of the level of all-trans-retinoic acid. Activities of the isomers on HL-60 cells to inhibit growth and to induce differentiation into granulocytes were parallel. all-trans-Retinoic acid and 9-cis-retinoic acid acted synergetically on HL-60 cells. Further, all-trans-retinoic acid acted additively with 13-cis-retinoic acid and with 9,13-di-cis-retinoic acid. In contrast, 9-cis-retinoic acid acted synergetically with 31-cis-retinoic acid and with 9,13-di-cis-retinoic acid.

引用

页码：81 / 86

页数：6

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