Can DNA polymerase I (Klenow fragment) serve as a model for other polymerases?

被引：34

作者：

Joyce, Catherine M. ^{[1
]}

机构：

[1] Yale Univ, Med Sch, Dept Mol Biophys & Biochem, 333 Cedar St, New Haven, CT 06510 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1991年 / 1卷 / 01期

关键词：

D O I：

10.1016/0959-440X(91)90020-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent protein-sequence comparisons suggest that a small number of important active-site residues may be conserved between all polymerases, even those of different classes.

引用

页码：123 / 129

页数：7

共 34 条

[1] PRIMARY STRUCTURAL RELATIONSHIPS MAY REFLECT SIMILAR DNA-REPLICATION STRATEGIES
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[2] IDENTIFICATION AND AMINO-ACID-SEQUENCE OF THE DEOXYNUCLEOSIDE TRIPHOSPHATE BINDING-SITE IN ESCHERICHIA-COLI DNA-POLYMERASE-I
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[3] STRUCTURAL AND FUNCTIONAL-RELATIONSHIPS BETWEEN PROKARYOTIC AND EUKARYOTIC DNA-POLYMERASES
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[4] A CONSERVED 3'-]5' EXONUCLEASE ACTIVE-SITE IN PROKARYOTIC AND EUKARYOTIC DNA-POLYMERASES
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[J]. CELL, 1989, 59 (01) : 219 - 228
[5] THE HIGHLY CONSERVED AMINO-ACID-SEQUENCE MOTIF TYR-GLY-ASP-THR-ASP-SER IN ALPHA-LIKE DNA-POLYMERASES IS REQUIRED BY PHAGE-PHI-29 DNA-POLYMERASE FOR PROTEIN-PRIMED INITIATION AND POLYMERIZATION
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[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4610 - 4614
[6] MECHANISTIC ASPECTS OF DNA-POLYMERASES - ESCHERICHIA-COLI DNA-POLYMERASE-I (KLENOW FRAGMENT) AS A PARADIGM
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BENKOVIC, SJ
[J]. CHEMICAL REVIEWS, 1990, 90 (07) : 1291 - 1307
[7] 3-DIMENSIONAL STRUCTURE OF ESCHERICHIA-COLI RNA-POLYMERASE HOLOENZYME DETERMINED BY ELECTRON CRYSTALLOGRAPHY
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[J]. NATURE, 1989, 340 (6236) : 730 - 732
[8] AN ATTEMPT TO UNIFY THE STRUCTURE OF POLYMERASES
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[J]. PROTEIN ENGINEERING, 1990, 3 (06): : 461 - 467
[9] THE 3'-5' EXONUCLEASE OF DNA-POLYMERASE-I OF ESCHERICHIA-COLI - CONTRIBUTION OF EACH AMINO-ACID AT THE ACTIVE-SITE TO THE REACTION
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[J]. EMBO JOURNAL, 1991, 10 (01) : 17 - 24
[10] GENETIC AND CRYSTALLOGRAPHIC STUDIES OF THE 3',5'-EXONUCLEOLYTIC SITE OF DNA-POLYMERASE-I
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[J]. SCIENCE, 1988, 240 (4849) : 199 - 201

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