THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND ITS RELEVANCE TO PARKINSONS-DISEASE

被引:81
作者
KINEMUCHI, H
FOWLER, CJ
TIPTON, KF
机构
[1] UNIV DUBLIN TRINITY COLL, DEPT BIOCHEM, DUBLIN 2, IRELAND
[2] SHOWA UNIV, SCH MED, DEPT PHARMACOL, SHINAGAWA KU, TOKYO 142, JAPAN
[3] ASTRA ALAB AB, DEV LABS, S-15185 SOLDERTALJE, SWEDEN
关键词
D O I
10.1016/0197-0186(87)90024-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:359 / 373
页数:15
相关论文
共 166 条
[61]   NEUROTOXICITY OF THE MEPERIDINE ANALOG N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].
HALLMAN, H ;
OLSON, L ;
JONSSON, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 97 (1-2) :133-136
[62]   NEUROCHEMICAL AND HISTOCHEMICAL CHARACTERIZATION OF NEUROTOXIC EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].
HALLMAN, H ;
LANGE, J ;
OLSON, L ;
STROMBERG, I ;
JONSSON, G .
JOURNAL OF NEUROCHEMISTRY, 1985, 44 (01) :117-127
[63]  
HARSING LG, 1979, POL J PHARMACOL PHAR, V31, P297
[64]   DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE IN MICE [J].
HEIKKILA, RE ;
HESS, A ;
DUVOISIN, RC .
SCIENCE, 1984, 224 (4656) :1451-1453
[65]   PREVENTION OF MPTP-INDUCED NEUROTOXICITY BY AGN-1133 AND AGN-1135, SELECTIVE INHIBITORS OF MONOAMINE OXIDASE-B [J].
HEIKKILA, RE ;
DUVOISIN, RC ;
FINBERG, JPM ;
YOUDIM, MBH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 116 (03) :313-317
[66]   STUDIES ON THE OXIDATION OF THE DOPAMINERGIC NEUROTOXIN 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE BY MONOAMINE OXIDASE-B [J].
HEIKKILA, RE ;
MANZINO, L ;
CABBAT, FS ;
DUVOISIN, RC .
JOURNAL OF NEUROCHEMISTRY, 1985, 45 (04) :1049-1054
[67]   DOPAMINERGIC TOXICITY OF ROTENONE AND THE 1-METHYL-4-PHENYLPYRIDINIUM ION AFTER THEIR STEREOTAXIC ADMINISTRATION TO RATS - IMPLICATION FOR THE MECHANISM OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE TOXICITY [J].
HEIKKILA, RE ;
NICKLAS, WJ ;
VYAS, I ;
DUVOISIN, RC .
NEUROSCIENCE LETTERS, 1985, 62 (03) :389-394
[68]  
HEIKKILA RE, 1984, NATURE, V311, P467, DOI 10.1038/311467a0
[69]   DOPAMINERGIC TOXICITY AFTER THE STEREOTAXIC ADMINISTRATION OF THE 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) TO RATS [J].
HEIKKILA, RE ;
NICKLAS, WJ ;
DUVOISIN, RC .
NEUROSCIENCE LETTERS, 1985, 59 (01) :135-140
[70]  
HEIKKILA RE, 1986, MPTP NEUROTOXIN PROD, P69