ENANTIOMER SEPARATIONS WITH CHROMATOGRAPHIC SUPPORTS BASED ON BETA-CYCLODEXTRIN POLYMERS IMMOBILIZED ON POROUS SILICA - ROLE OF THE POLYMER STRUCTURE IN SEPARATING ABILITY

被引：35

作者：

THUAUD, N

SEBILLE, B

DERATANI, A

POPPING, B

PELLET, C

机构：

[1] Laboratoire de Physico-Chimie des Biopolymères, U.M.R. 27, C.N.R.S., Université de Paris XII, Thiais, 94320, 2, rue Henri Dunant

来源：

CHROMATOGRAPHIA | 1993年 / 36卷

关键词：

COLUMN LIQUID CHROMATOGRAPHY; CHIRAL SEPARATION; BETA-CYCLODEXTRIN POLYMERS; ORGANIC COMPOUNDS;

D O I：

10.1007/BF02263896

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Two beta-cyclodextrin (beta-CD)-containing polymers have been prepared either by condensation of beta-CD molecules with a bifunctional reagent or by grafting a beta-CD derivative on to a linear polymer (polyvinylimidazole). HPLC stationary phases were obtained by adsorption of the beta-CD polymers on to silica. The ability of these chromatographic supports to resolve racemic mixtures of organic compounds such as amino acid derivatives, phenylhydantoins, barbiturates, and hydroxycoumarin derivatives has been investigated. Results were found to depend on the chemical structure of the beta-CD polymers

引用

页码：373 / 380

页数：8

共 22 条

[1]

Armstrong D. W., 1985, US Pat., Patent No. [4 539 399, 4539399, 4,539,399]

[2] SEPARATION OF DRUG STEREOISOMERS BY THE FORMATION OF BETA-CYCLODEXTRIN INCLUSION COMPLEXES [J].

ARMSTRONG, DW ;

WARD, TJ ;

ARMSTRONG, RD ;

BEESLEY, TE .

SCIENCE, 1986, 232 (4754) :1132-1135

[3] CYCLODEXTRIN BONDED PHASES FOR THE LIQUID-CHROMATOGRAPHIC SEPARATION OF OPTICAL, GEOMETRICAL, AND STRUCTURAL ISOMERS [J].

ARMSTRONG, DW ;

DEMOND, W .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1984, 22 (09) :411-415

[4] (R)-NAPHTHYLETHYLCARBAMATE-SUBSTITUTED AND (S)-NAPHTHYLETHYLCARBAMATE-SUBSTITUTED BETA-CYCLO-DEXTRIN BONDED STATIONARY PHASES FOR THE REVERSED-PHASE LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS [J].

ARMSTRONG, DW ;

CHANG, CD ;

LEE, SH .

JOURNAL OF CHROMATOGRAPHY, 1991, 539 (01) :83-90

[5] DERIVATIZED CYCLODEXTRINS FOR NORMAL-PHASE LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS [J].

ARMSTRONG, DW ;

STALCUP, AM ;

HILTON, ML ;

DUNCAN, JD ;

FAULKNER, JR ;

CHANG, SC .

ANALYTICAL CHEMISTRY, 1990, 62 (15) :1610-1615

[6] CYCLODEXTRIN CHIRAL STATIONARY PHASES FOR LIQUID-CHROMATOGRAPHIC SEPARATIONS OF DRUG STEREOISOMERS [J].

BERTHOD, A ;

JIN, HL ;

BEESLEY, TE ;

DUNCAN, JD ;

ARMSTRONG, DW .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, 8 (02) :123-130

[7]

CABRERA K, 1990, INT LAB JUL, P28

[8] RETENTION BEHAVIOR AND CHIRAL RECOGNITION MECHANISM OF SEVERAL CYCLODEXTRIN-BONDED STATIONARY PHASES FOR DANSYL AMINO-ACIDS [J].

FUJIMURA, K ;

SUZUKI, S ;

HAYASHI, K ;

MASUDA, S .

ANALYTICAL CHEMISTRY, 1990, 62 (20) :2198-2205

[9] STRUCTURAL FACTORS AFFECTING CHIRAL RECOGNITION AND SEPARATION ON BETA-CYCLODEXTRIN BONDED PHASES [J].

HAN, SM ;

HAN, YI ;

ARMSTRONG, DW .

JOURNAL OF CHROMATOGRAPHY, 1988, 441 (02) :376-381

[10]

HARADA A, 1981, POLYM J, V13, P77

← 1 2 3 →