AFLATOXIN B-1-INDUCED 8-HYDROXYDEOXYGUANOSINE FORMATION IN RAT HEPATIC DNA

被引：151

作者：

SHEN, HM ^{[1
]}

ONG, CN ^{[1
]}

LEE, BL ^{[1
]}

SHI, CY ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,DEPT COMMUNITY OCCUPAT & FAMILY MED,SINGAPORE 0511,SINGAPORE

来源：

CARCINOGENESIS | 1995年 / 16卷 / 02期

关键词：

D O I：

10.1093/carcin/16.2.419

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A time- and dose-dependent increase in 8-hydroxydeoxyguanosine (8-OHdG) was observed in rat hepatic DNA after a single i.p. injection of aflatoxin B-1 (AFB(1)). It was also found that pre-treatment with selenium or deferoxamine significantly reduced 8-OHdG level in AFB(1)-administered rats. In contrast, no reduction in 8-OHdG concentration was found in vitamin E-pre-treated rats. These results provide evidence that AFB(1) causes oxidative DNA damage in rat liver, which may involve hydroxyl radicals as the initiating species. It is postulated that AFB(1)-induced oxidative DNA damage (8-OHdG formation) may constitute an important pathway in AFB(1) hepatocarcinogenesis.

引用

页码：419 / 422

页数：4