共 31 条
INTEGRINS AND MODULATION OF TRANSMITTER RELEASE FROM MOTOR-NERVE TERMINALS BY STRETCH
被引:107
作者:
CHEN, BM
GRINNELL, AD
机构:
[1] UNIV CALIF LOS ANGELES, SCH MED, JERRY LEWIS NEUROMUSCULAR RES CTR, LOS ANGELES, CA 90024 USA
[2] UNIV CALIF LOS ANGELES, SCH MED, AHMANSON LAB NEUROBIOL, LOS ANGELES, CA 90024 USA
来源:
关键词:
D O I:
10.1126/science.7667637
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The stretch of a frog muscle within the physiological range can more than double the spontaneous and evoked release of neurotransmitter from its motor nerve terminals. Here, stretch enhancement of release was suppressed by peptides containing the sequence arginine-glycine-aspartic acid (RGD), which blocks integrin binding. Integrin antibodies also inhibited the enhancement obtained by stretching. Stretch enhancement depended on intraterminal calcium derived both from external calcium and from internal stores. Muscle stretch thus might enhance the release of neurotransmitters either by elevating internal calcium concentrations or by increasing the sensitivity of transmitter release to calcium in the nerve terminal.
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页码:1578 / 1580
页数:3
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