IN-VIVO POTENT ANTIMALARIAL 1,2,4-TRIOXANES - SYNTHESIS AND ACTIVITY OF 8-(ALPHA-ARYLVINYL)6,7,10-TRIOXASPIRO,[4,5]DECANES AND 3-(ALPHA-ARYLVINYL)-1,2,5-TRIOXASPIRO[5,5]UNDECANES AGAINST PLASMODIUM-BERGHEI IN MICE

被引：39

作者：

SINGH, C

MISRA, D

SAXENA, G

CHANDRA, S

机构：

[1] Central Drug Research Institute, Lucknow

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 17期

关键词：

D O I：

10.1016/0960-894X(95)00322-K

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fourteen new trioxanes belonging to 6,7,10-trioxaspiro[4,5]decane and 1,2,5-trioxaspiro[5,5]undecane series have been synthesized and screened against Plesmodium berghei in mice. Several of these trioxanes show promising blood schizontocidal activity.

引用

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页码：1913 / 1916

页数：4

相关论文

共 24 条

[1] SIMPLIFIED ANALOGS OF THE ANTIMALARIAL ARTEMISININ - SYNTHESIS OF 6,9-DESMETHYLARTEMISININ [J].

AVERY, MA ;

JENNINGSWHITE, C ;

CHONG, WKM .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (08) :1792-1795

[2] 6-HYDROXYMETHYL-1,2,4-TRIOXANES AND DERIVATIVES - AN ALTERNATIVE 1,2,4-TRIOXANE SYNTHESIS FORM BETA-GAMMA-UNSATURATED BETA-HYDROXYHYDROPEROXIDES [J].

BLOODWORTH, AJ ;

JOHNSON, KA .

TETRAHEDRON LETTERS, 1994, 35 (43) :8057-8060

[3] SYNTHESIS OF 1,2,4-TRIOXANES VIA INTRAMOLECULAR OXYMERCURIATION [J].

BLOODWORTH, AJ ;

SHAH, A .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (14) :947-948

[4]

BUNELLE WH, 1991, J AM CHEM SOC, V113, P8168

[5] ARTEMISININ (QINGHAOSU) - A NEW TYPE OF ANTIMALARIAL DRUG [J].

BUTLER, AR ;

WU, YL .

CHEMICAL SOCIETY REVIEWS, 1992, 21 (02) :85-90

[6] SYNTHESIS AND REACTION OF 1,2,4-TRIOXANES [J].

FUJISAKA, T ;

MIURA, M ;

NOJIMA, M ;

KUSABAYASHI, S .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (05) :1031-1039

[7] REACTION OF SINGLET OXYGEN WITH ENOL ETHERS IN THE PRESENCE OF ACETALDEHYDE - FORMATION OF 1,2,4-TRIOXANES [J].

JEFFORD, CW ;

KOHMOTO, S ;

BOUKOUVALAS, J ;

BURGER, U .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (21) :6498-6499

[8] THE PHOTOOXYGENATION OF OLEFINS AND THE ROLE OF ZWITTERIONIC PEROXIDES [J].

JEFFORD, CW .

CHEMICAL SOCIETY REVIEWS, 1993, 22 (01) :59-66

[9] 1,2,4-TRIOXANES AS POTENTIAL ANTIMALARIAL AGENTS [J].

KEPLER, JA ;

PHILIP, A ;

LEE, YW ;

MOREY, MC ;

CARROLL, FI .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (04) :713-716

[10] QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA [J].

KLAYMAN, DL .

SCIENCE, 1985, 228 (4703) :1049-1055