PEMPHIGUS-VULGARIS ANTIGEN IS A DESMOSOMAL DESMOGLEIN

被引：15

作者：

KARPATI, S ^{[1
]}

AMAGAI, M ^{[1
]}

PRUSSICK, R ^{[1
]}

STANLEY, JR ^{[1
]}

机构：

[1] NIH,DERMATOL BRANCH,BETHESDA,MD 20892

来源：

DERMATOLOGY | 1994年 / 189卷

关键词：

PEMPHIGUS VULGARIS ANTIGEN; DESMOSOMES; DESMOGLEIN; CADHERINS;

D O I：

10.1159/000246923

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Because pemphigus vulgaris antigen (PVA) is homologous to desmogleins which are in desmosomes, we asked whether PVA is also localized to desmosomes. Immunogold electron microscopy was used to localize binding of PV antibodies. Rabbit antibodies raised against fusion proteins containing the extracellular portion of PVA bound to desmosomes of cultured keratinocytes. PV patient serum affinity-purified on one of these fusion proteins and injected into neonatal mice localized to separating desmosomes. These results show that PVA belongs to the desmoglein subfamily of cadherins according to sequence, localization and, presumably, function.

引用

页码：24 / 26

页数：3

共 13 条

[11] EXPERIMENTALLY INDUCED PEMPHIGUS VULGARIS IN NEONATAL BALB/C MICE - A TIME-COURSE STUDY OF CLINICAL, IMMUNOLOGICAL, ULTRASTRUCTURAL, AND CYTOCHEMICAL CHANGES [J].