EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (EAE) IN MICE LACKING CD4+ T-CELLS

被引:24
作者
KOH, DR
HO, A
RAHEMTULLA, A
PENNINGER, J
MAK, TW
机构
[1] UNIV TORONTO,AMGEN RES INST,TORONTO M4X 1K9,ON,CANADA
[2] UNIV TORONTO,ONTARIO CANC INST,TORONTO,ON,CANADA
[3] UNIV TORONTO,DEPT MED BIOPHYS & IMMUNOL,TORONTO,ON,CANADA
关键词
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CD4; KNOCKOUT MICE;
D O I
10.1002/eji.1830240947
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Like most experimental autoimmune disease experimental allergic encephalomyelitis (EAE) has been shown to be mediated by CD4(+) helper T cells. In vivo antibody blocking studies with anti-CD4 and adoptive transfer of activated CD4(+) T cells indicate the importance of CD4(+) cells in disease induction. Fourth backcross generation mutant CD4-/- PL/J mice were immunized with myelin basic protein. Despite the lack CD4(+) T cells some of these mice developed EAE, albeit, at a considerably reduced frequency and with variable severity. Furthermore, antigen-specific T cell proliferation can be demonstrated, indicating some residual helper activity that is major histocompatibility complex class II restricted. This demonstrates that, although the CD4(+) T cell is the prime effector cell in EAE, in mice developmentally lacking in CD4, the expanded double-negative T cells may subserve helper and effector functions.
引用
收藏
页码:2250 / 2253
页数:4
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