CEREBROSPINAL-FLUID PROTEINS IN MEN WITH CHRONIC ENCEPHALOPATHY AFTER EXPOSURE TO ORGANIC-SOLVENTS

被引：11

作者：

BARREGARD, L

WIKKELSO, C

ROSENGREN, LE

AURELL, A

THIRINGER, G

NILSON, L

SALLSTEN, G

HAGLID, KG

BLOMSTRAND, C

机构：

[1] GOTHENBURG UNIV, SAHLGRENS HOSP, DEPT NEUROL, S-41345 GOTHENBURG, SWEDEN

[2] GOTHENBURG UNIV, DEPT NEUROBIOL, S-41124 GOTHENBURG, SWEDEN

来源：

SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH | 1990年 / 16卷 / 06期

关键词：

Blood-brain barrier; glial fibrillary acidic protein; neurotoxicity; occupational;

D O I：

10.5271/sjweh.1765

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Cerebrospinal fluid was examined for 23 patients with chronic toxic encephalopathy after heavy exposure to organic solvents and 23 healthy age-matched referents. No differences were found between the patients and referents with respect to the levels of albumin, immunoglobulin, prealbumin, alpha-1-antitrypsin, beta-2-microglobulin, haptoglobin, or the astroglial cell proteins S100 and glial fibrillary acidic protein in the cerebrospinal fluid. The albumin ratio was normal for both the patients and the referents. The patient group had had heavy exposure to organic solvents, but its members had not been exposed for at least one year before the study. It was concluded that, if exposure to organic solvents affects proteins in cerebrospinal fluid, such effects are probably reversible.

引用

页码：423 / 427

页数：5