NOVEL BINDING MODE OF HIGHLY POTENT HIV-PROTEINASE INHIBITORS INCORPORATING THE (R)-HYDROXYETHYLAMINE ISOSTERE

被引：191

作者：

KROHN, A ^{[1
]}

REDSHAW, S ^{[1
]}

RITCHIE, JC ^{[1
]}

GRAVES, BJ ^{[1
]}

HATADA, MH ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,ROCHE RES CTR,NUTLEY,NJ 07110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 11期

关键词：

D O I：

10.1021/jm00115a028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3340 / 3342

页数：3

共 15 条

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[8] STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A SUBSTRATE-BASED INHIBITOR AT 2.3-A RESOLUTION
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[J]. SCIENCE, 1989, 246 (4934) : 1149 - 1152
[9] NATARAJAN S, 1988, PEPTIDES CHEM BIOL, P131
[10] HYDROXYETHYLAMINE ANALOGS OF THE P17/P24 SUBSTRATE CLEAVAGE SITE ARE TIGHT-BINDING INHIBITORS OF HIV PROTEASE
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[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) : 1285 - 1288

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