INTERNAL HYDROGEN ABSTRACTION BY ACTIVATED NEOCARZINOSTATIN - QUENCHING OF THE RADICAL AT C2 BY HYDROGEN-ATOM TRANSFER FROM THE ALPHA-CARBON OF THE ADDUCTED THIOL

被引：32

作者：

CHIN, DH ^{[1
]}

GOLDBERG, IH ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 05期

关键词：

D O I：

10.1021/ja00031a074

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：1914 / 1915

页数：2

共 14 条

[1] ATHERTON E, 1989, SOLID PHASE PEPTIDE, P60
[2] SITES IN THE DIYNE ENE BICYCLIC CORE OF NEOCARZINOSTATIN CHROMOPHORE RESPONSIBLE FOR HYDROGEN ABSTRACTION FROM DNA
CHIN, DH
ZENG, CH
COSTELLO, CE
GOLDBERG, IH
[J]. BIOCHEMISTRY, 1988, 27 (21) : 8106 - 8114
[3] DEDON PC, 1990, J BIOL CHEM, V265, P14713
[4] DEGRAFF WG, 1985, J BIOL CHEM, V260, P8312
[5] MECHANISM OF NEOCARZINOSTATIN ACTION - ROLE OF DNA MICROSTRUCTURE IN DETERMINATION OF CHEMISTRY OF BISTRANDED OXIDATIVE DAMAGE
GOLDBERG, IH
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (07) : 191 - 198
[6] MECHANISM OF ACTIVATION OF THE ANTITUMOR ANTIBIOTIC NEOCARZINOSTATIN BY MERCAPTAN AND SODIUM-BOROHYDRIDE
HENSENS, OD
GOLDBERG, IH
[J]. JOURNAL OF ANTIBIOTICS, 1989, 42 (05) : 761 - 768
[7] NEOCARZINOSTATIN CHROMOPHORE - PRESENCE OF A HIGHLY STRAINED ETHER RING AND ITS REACTION WITH MERCAPTAN AND SODIUM-BOROHYDRIDE
HENSENS, OD
DEWEY, RS
LIESCH, JM
NAPIER, MA
REAMER, RA
SMITH, JL
ALBERSSCHONBERG, G
GOLDBERG, IH
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 113 (02) : 538 - 547
[8] A CONVENIENT PREPARATION OF S-BENZHYDRYL- AND S-TRITYL-L-CYSTEINE
HISKEY, RG
ADAMS, JB
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (04) : 1340 - &
[9] MECHANISM AND BASE SPECIFICITY OF DNA BREAKAGE IN INTACT-CELLS BY NEOCARZINOSTATIN
KAPPEN, LS
ELLENBERGER, TE
GOLDBERG, IH
[J]. BIOCHEMISTRY, 1987, 26 (02) : 384 - 390
[10] SELECTIVE ABSTRACTION OF H-2 FROM C-5' OF THYMIDYLATE IN AN OLIGODEOXYNUCLEOTIDE BY THE RADICAL CENTER AT C-6 OF THE DIRADICAL SPECIES OF NEOCARZINOSTATIN - CHEMICAL EVIDENCE FOR THE STRUCTURE OF THE ACTIVATED DRUG DNA COMPLEX
MESCHWITZ, SM
GOLDBERG, IH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) : 3047 - 3051

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