TREATMENT OF ACUTE SPINAL-CORD INJURIES - COMPARISON OF THYROTROPIN-RELEASING-HORMONE AND NIMODIPINE

被引：16

作者：

CEYLAN, S ^{[1
]}

ILBAY, K ^{[1
]}

BAYKAL, S ^{[1
]}

CEYLAN, S ^{[1
]}

SENER, U ^{[1
]}

OZMENOGLU, M ^{[1
]}

KALELIOGLU, M ^{[1
]}

AKTURK, F ^{[1
]}

KOMSUOGLU, SS ^{[1
]}

OZORAN, A ^{[1
]}

机构：

[1] KARADENIZ TEKN UNIV, FAC MED, DEPT NEUROL & HISTOL, TRABZON 61080, TURKEY

来源：

RESEARCH IN EXPERIMENTAL MEDICINE | 1992年 / 192卷 / 01期

关键词：

SPINAL CORD INJURY; TRH; NIMODIPINE; CLIP COMPRESSION;

D O I：

10.1007/BF02576254

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of nimodipine and thyrotropin-releasing hormone (TRH) were compared in a clip-compression model of experimental spinal cord injuries (SCI) in rats. Thirty rats received a 50-g clip-compression injury on the cord at T9. Ten rats were given 0.02 mg/kg nimodipine and dextran 40 (3 ml) i.v. 1 h after injury. Ten rats were given 2 mg/kg TRH and dextran 40 (3 ml) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. The remaining ten rats were given only saline. TRH treatment significantly improved somatosensory-evoked potentials (SEPs) and mean arterial blood pressures (MABPs), whereas nimodipine treatment had no effect on these variables (Fisher's exact test (P < 0.01).

引用

页码：23 / 33

页数：11

共 33 条

[1]

Anderson D.K., 1983, NEUROCHEM PATHOL, V1, P249

[2] SPINAL-CORD INJURY AND PROTECTION [J].

ANDERSON, DK ;

DEMEDIUK, P ;

SAUNDERS, RD ;

DUGAN, LL ;

MEANS, ED ;

HORROCKS, LA .

ANNALS OF EMERGENCY MEDICINE, 1985, 14 (08) :816-821

[3] EXPERIMENTAL SPINAL-CORD INJURY - EFFECT OF A CALCIUM-CHANNEL ANTAGONIST (NICARDIPINE) [J].

BLACK, P ;

MARKOWITZ, RS ;

FINKELSTEIN, SD ;

MCMONAGLESTRUCKO, K ;

GILLESPIE, JA .

NEUROSURGERY, 1988, 22 (01) :61-66

[4]

BOYER CE, 1982, FED PROC, V41, P1080

[5] MEDICAL-TREATMENT OF ACUTE SPINAL-CORD INJURIES [J].

CEYLAN, S ;

KALELIOGLU, M ;

AKTURK, G ;

AKTURK, F ;

CEYLAN, S .

RESEARCH IN EXPERIMENTAL MEDICINE, 1990, 190 (02) :111-119

[6] A REVIEW AND UPDATE OF EXPERIMENT AND CLINICAL-STUDIES OF SPINAL-CORD INJURY [J].

COLLINS, WF .

PARAPLEGIA, 1983, 21 (04) :204-219

[7] EXPERIMENTAL SPINAL-CORD INJURY - EFFECTS OF TRAUMA OR ISCHEMIA ON TRH AND MUSCARINIC RECEPTORS [J].

FADEN, AI ;

PILOTTE, NS ;

BURT, DR .

NEUROLOGY, 1986, 36 (05) :723-726

[8] EFFECT OF TRH ANALOGS ON NEUROLOGIC RECOVERY AFTER EXPERIMENTAL SPINAL TRAUMA [J].

FADEN, AI ;

JACOBS, TP .

NEUROLOGY, 1985, 35 (09) :1331-1334

[9] EVALUATION OF THE CALCIUM-CHANNEL ANTAGONIST NIMODIPINE IN EXPERIMENTAL SPINAL-CORD ISCHEMIA [J].

FADEN, AI ;

JACOBS, TP ;

SMITH, MT .

JOURNAL OF NEUROSURGERY, 1984, 60 (04) :796-799

[10]

FADEN AI, 1990, J PHARMACOL EXP THER, V255, P608

← 1 2 3 4 →