TREATMENT OF ACUTE SPINAL-CORD INJURIES - COMPARISON OF THYROTROPIN-RELEASING-HORMONE AND NIMODIPINE

被引：16

作者：

CEYLAN, S ^{[1
]}

ILBAY, K ^{[1
]}

BAYKAL, S ^{[1
]}

CEYLAN, S ^{[1
]}

SENER, U ^{[1
]}

OZMENOGLU, M ^{[1
]}

KALELIOGLU, M ^{[1
]}

AKTURK, F ^{[1
]}

KOMSUOGLU, SS ^{[1
]}

OZORAN, A ^{[1
]}

机构：

[1] KARADENIZ TEKN UNIV, FAC MED, DEPT NEUROL & HISTOL, TRABZON 61080, TURKEY

来源：

RESEARCH IN EXPERIMENTAL MEDICINE | 1992年 / 192卷 / 01期

关键词：

SPINAL CORD INJURY; TRH; NIMODIPINE; CLIP COMPRESSION;

D O I：

10.1007/BF02576254

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of nimodipine and thyrotropin-releasing hormone (TRH) were compared in a clip-compression model of experimental spinal cord injuries (SCI) in rats. Thirty rats received a 50-g clip-compression injury on the cord at T9. Ten rats were given 0.02 mg/kg nimodipine and dextran 40 (3 ml) i.v. 1 h after injury. Ten rats were given 2 mg/kg TRH and dextran 40 (3 ml) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. The remaining ten rats were given only saline. TRH treatment significantly improved somatosensory-evoked potentials (SEPs) and mean arterial blood pressures (MABPs), whereas nimodipine treatment had no effect on these variables (Fisher's exact test (P < 0.01).

引用

页码：23 / 33

页数：11

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