SYNTHESIS OF NOVEL CITRATE-BASED SIDEROPHORES AND SIDEROPHORE-BETA-LACTAM CONJUGATES - IRON TRANSPORT-MEDIATED DRUG-DELIVERY SYSTEMS

被引：24

作者：

GHOSH, A ^{[1
]}

MILLER, MJ ^{[1
]}

机构：

[1] UNIV NOTRE DAME,DEPT CHEM & BIOCHEM,NOTRE DAME,IN 46556

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 27期

关键词：

D O I：

10.1021/jo00079a007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of analogs of arthrobactin (5), a microbial iron chelator, and its imide 8 are described. The differentially protected citric acid residue 31 served as the key intermediate in making conjugates having a generalized structure 14 with two representative carbacephalosporin units, 15 and 16. Both conjugates, 49 and 51, showed antibiotic activity, while conjugate 51 obtained from beta-lactam 16 bearing a phenylglycyl side chain was shown to be more effective.

引用

页码：7652 / 7659

页数：8

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