SYNTHESIS OF 3-EPISIASTATIN-B ANALOGS HAVING ANTIINFLUENZA VIRUS ACTIVITY

被引：14

作者：

NISHIMURA, Y

UMEZAWA, Y

KONDO, S

TAKEUCHI, T

MORI, K

KIJIMASUDA, I

TOMITA, K

SUGAWARA, K

NAKAMURA, K

机构：

[1] MECT CORP,TOKYO RES INST,TOKOROZAWA,SAITAMA 359,JAPAN

[2] YAMAGATA UNIV,SCH MED,DEPT BACTERIOL,IIDA,YAMAGATA 99023,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 12期

关键词：

D O I：

10.7164/antibiotics.46.1883

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.

引用

页码：1883 / 1889

页数：7

共 22 条

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