QUANTIFICATION OF LIVER FAT USING MAGNETIC-RESONANCE SPECTROSCOPY

被引：279

作者：

THOMSEN, C

BECKER, U

WINKLER, K

CHRISTOFFERSEN, P

JENSEN, M

HENRIKSEN, O

机构：

[1] Danish Research Center of Magnetic Resonance, Hvidovre Hospital, University of Copenhagen

[2] Alcohol Unit, Department of Medical Gastroenterology, Hvidovre Hospital

[3] Department of Clinical Physiology, Hvidovre Hospital, University of Copenhagen

[4] Department of Pathology, Hvidovre Hospital, University of Copenhagen

来源：

MAGNETIC RESONANCE IMAGING | 1994年 / 12卷 / 03期

关键词：

MAGNETIC RESONANCE SPECTROSCOPY; LIVER FAT;

D O I：

10.1016/0730-725X(94)92543-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Localized proton MR spectroscopy using stimulated echoes was used to quantify the liver fat concentration in patients with various degrees of fatty liver due to alcohol abuse. Ten patients underwent a liver biopsy followed by chemical triglyceride estimation of the fatty content. A statistically significant correlation was found between the fat concentration measured in the liver biopsies, and the concentration calculated from the spectroscopic experiments (r = 0.9, p <.001). Quantitative assessment of liver fat concentrations using localized spectroscopy is superior to methods based on differences in relaxation times, and can be used to estimate the fat concentration over the full range of fat content in contrast to the spectroscopic imaging methods. Localized spectroscopy may replace liver biopsy in the diagnosis of diffuse fatty infiltrations, and can be used for follow-up, due to its noninvasive nature.

引用

页码：487 / 495

页数：9

共 39 条

[21]

Dixon, Simple proton spectroscopic imaging, Radiology, 153, pp. 189-194, (1984)

[22]

Frahm, Merboldt, Hanicke, Localized proton spectroscopy using stimulated echoes, J. Magn. Reson., 72, pp. 502-508, (1987)

[23]

Barany, Venkatasubramanian, Mok, Siegel, Abraham, Wycliffe, Mafee, Quantitative and qualitative fat analysis in human leg muscle of neuromuscular diseases by 1H MR spectroscopy in vivo, Magn. Reson. Med., 10, pp. 210-226, (1989)

[24]

Jensen, Stenver, Jensen, Grundtvig, Thomsen, Karle, Henriksen, Nielsen, Effects of recombinant human erythropoietin on the haemopoietic bone marrow monitored by magnetic resonance spectroscopy in patients with end-stage renal disease, Magn. Reson. Imaging, 8, pp. 237-243, (1990)

[25]

Longo, Ricci, Masutti, Et al., Fatty infiltration of the liver: Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography, Invest. Radiol., 28, pp. 297-302, (1993)

[26]

Hazle, Narayana, Dunsford, Chronic carbon tetrachloride and phospholipase D hepatotoxicity in rat: In vivo 1H magnetic resonance, total lipid analysis, and histology, Magn. Reson. Med., 15, pp. 211-228, (1990)

[27]

Bruhn, Frahm, Gyngell, Merboldt, Hanicke, Sauter, Localized proton NMR spectroscopy using stimulated echoes: Applications to human skeletal muscle in vivo, Magn. Reson. Med., 17, pp. 82-94, (1991)

[28]

Thomson, Jensen, Jensen, Olesen, Henriksen, MR muscle sequences for selective relaxation time measurements: A phantom study, Magn. Reson. Imaging, 8, pp. 43-50, (1990)

[29]

Thomsen, Henriksen, Ring, In vivo measurements of relaxation process in the human liver by MRI. The role of respiratory gating/triggering, Magn. Reson. Imaging, 6, pp. 431-436, (1988)

[30]

Hahn, Spin Echoes, Phys. Rev., 80, pp. 580-594, (1950)

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