SPIROACETAL SYNTHESIS FROM A KEY LACTONE INTERMEDIATE LEADING TO NOVEL C24 AND C25-SUBSTITUTED MILBEMYCINS

被引：11

作者：

BAKER, GH

HUSSAIN, N

MACAULAY, GS

MORGAN, DO

DORGAN, RJJ

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, EPSOM KT18 5XQ, SURREY, ENGLAND

[2] SMITHKLINE BEECHAM ANIM HLTH, SURREY KT20 7NT, ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85225-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The lactone intermediates (3), (4) and (5) are converted via lithium acetylide chemistry to a range of novel C24 and C25-substituted milbemycins. The methodology has been extended to afford milbemycins containing 6,5-spiroacetal units.

引用

页码：2381 / 2384

页数：4

共 8 条

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