MECHANISM OF ACTION OF SERINE PROTEASES - TETRAHEDRAL INTERMEDIATE AND CONCERTED PROTON-TRANSFER

被引：110

作者：

HUNKAPILLER, MW ^{[1
]}

FORGAC, MD ^{[1
]}

RICHARDS, JH ^{[1
]}

机构：

[1] CALTECH, CHURCH LABS CHEM BIOL, PASADENA, CA 91125 USA

来源：

BIOCHEMISTRY | 1976年 / 15卷 / 25期

关键词：

D O I：

10.1021/bi00670a024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：5581 / 5588

页数：8

共 26 条

[1] ROLE OF A BURIED ACID GROUP IN MECHANISM OF ACTION OF CHYMOTRYPSIN [J].

BLOW, DM ;

BIRKTOFT, JJ ;

HARTLEY, BS .

NATURE, 1969, 221 (5178) :337-&

[2] MODE OF ACTION OF SOYBEAN TRYPSIN-INHIBITOR (KUNITZ) AS A MODEL FOR SPECIFIC PROTEIN-PROTEIN INTERACTIONS [J].

BLOW, DM ;

JANIN, J ;

SWEET, RM .

NATURE, 1974, 249 (5452) :55-57

[3] CHYMOTRYPSIN CATALYSIS . EVIDENCE FOR A NEW INTERMEDIATE [J].

CAPLOW, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (13) :3639-&

[4]

ELROD JP, 1975, FARADAY S CHEM SOC, P10

[5] MECHANISM OF CHYMOTRYPSIN - STRUCTURE, REACTIVITY, AND NONPRODUCTIVE BINDING RELATIONSHIPS [J].

FASTREZ, J ;

FERSHT, AR .

BIOCHEMISTRY, 1973, 12 (06) :1067-1074

[6] MECHANISM OF ALPHA-CHYMOTRYPSIN-CATALYZED HYDROLYSIS OF AMIDES - PH DEPENDENCE OF KC AND KM - KINETIC DETECTION OF AN INTERMEDIATE [J].

FERSHT, AR ;

REQUENA, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (25) :7079-+

[7] COUPLING OF PROTON MOTIONS IN CATALYTIC ACTIVATED COMPLEXES - MODEL POTENTIAL-ENERGY SURFACES FOR HYDROGEN-BOND CHAINS [J].

GANDOUR, RD ;

MAGGIORA, GM ;

SCHOWEN, RL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (22) :6967-6979

[8]

GOLD V, 1969, ADV PHYS ORG CHEM, V9, P259

[9] CARBON NUCLEAR MAGNETIC-RESONANCE STUDIES OF HISTIDINE RESIDUE IN ALPHA-LYTIC PROTEASE - IMPLICATIONS FOR CATALYTIC MECHANISM OF SERINE PROTEASES [J].

HUNKAPILLER, MW ;

SMALLCOMBE, SH ;

WHITAKER, DR ;

RICHARDS, JH .

BIOCHEMISTRY, 1973, 12 (23) :4732-4743

[10] MECHANISM OF SERINE PROTEASE ACTION - IONIZATION BEHAVIOR OF TETRAHEDRAL ADDUCT BETWEEN ALPHA-LYTIC PROTEASE AND TRIPEPTIDE ALDEHYDE STUDIED BY C-13 MAGNETIC-RESONANCE [J].

HUNKAPILLER, MW ;

SMALLCOMBE, SH ;

RICHARDS, JH .

ORGANIC MAGNETIC RESONANCE, 1975, 7 (06) :262-265

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