CORRECTION OF COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY WITH A COBALAMIN ANALOG THAT BINDS WITH HIGH AFFINITY TO R-PROTEIN BUT NOT TO INTRINSIC-FACTOR - INVIVO EVIDENCE THAT A FAILURE TO PARTIALLY DEGRADE R-PROTEIN IS RESPONSIBLE FOR COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY

被引：85

作者：

ALLEN, RH

SEETHARAM, B

ALLEN, NC

PODELL, ER

ALPERS, DH

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL,ST LOUIS,MO 63110

[2] UNIV COLORADO,MED CTR,DEPT MED,DIV HEMATOL,DENVER,CO 80262

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1978年 / 61卷 / 06期

关键词：

D O I：

10.1172/JCI109083

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

收藏

页码：1628 / 1634

页数：7

相关论文

共 16 条

[1] Allen R H, 1975, Prog Hematol, V9, P57
[2] EFFECT OF PROTEOLYTIC-ENZYMES ON BINDING OF COBALAMIN TO R-PROTEIN AND INTRINSIC-FACTOR - INVITRO EVIDENCE THAT A FAILURE TO PARTIALLY DEGRADE R-PROTEIN IS RESPONSIBLE FOR COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY
ALLEN, RH
SEETHARAM, B
PODELL, E
ALPERS, DH
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (01) : 47 - 54
[3] ALLEN RH, 1977, BLOOD, V50, P88
[4] BURGER RL, 1974, J BIOL CHEM, V249, P7220
[5] MALABSORPTION OF CRYSTALLINE VITAMIN-B12 IN CYSTIC-FIBROSIS
DEREN, JJ
ARORA, B
TOSKES, PP
HANSELL, J
SIBINGA, MS
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1973, 288 (18) : 949 - 950
[6] GILBERT HS, 1974, BLOOD, V44, P926
[7] NATURE OF VITAMIN B12 BINDING .3. THERMODYNAMICS OF BINDING TO HUMAN INTRINSIC FACTOR AND TRANSCOBALAMINS
HIPPE, E
OLESEN, H
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1971, 243 (01) : 83 - &
[8] ISOLATION AND CHARACTERIZATION OF AN ABNORMAL HUMAN INTRINSIC-FACTOR
KATZ, M
MEHLMAN, CS
ALLEN, RH
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1974, 53 (05) : 1274 - 1283
[9] ABSORPTION, PLASMA TRANSPORT, AND CELLULAR RETENTION OF COBALAMIN ANALOGS IN RABBIT - EVIDENCE FOR EXISTENCE OF MULTIPLE MECHANISMS THAT PREVENT ABSORPTION AND TISSUE DISSEMINATION OF NATURALLY OCCURRING COBALAMIN ANALOGS
KOLHOUSE, JF
ALLEN, RH
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (06) : 1381 - 1392
[10] MATUCHANSKY C, 1974, GASTROENTEROLOGY, V67, P406