SMALL RNA HELICES AS SUBSTRATES FOR AMINOACYLATION AND THEIR RELATIONSHIP TO CHARGING OF TRANSFER-RNAS

被引：41

作者：

FRANCKLYN, C

MUSIERFORSYTH, K

SCHIMMEL, P

机构：

[1] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

[2] UNIV VERMONT, COLL MED, DEPT BIOCHEM, BURLINGTON, VT 05405 USA

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1992年 / 206卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1992.tb16929.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA microhelices that reconstruct the acceptor stems of transfer RNAs can be aminoacylated. The anticodon-independent aminoacylation is sequence-specific and suggests a relationship between amino acids and nucleotide sequences which is different from that of the classical genetic code. The specific aminoacylation of RNA microhelices also suggests a highly differentiated adaptation of the structures of aminoacyl-tRNA synthetases to sequences in the acceptor stems of transfer RNAs.

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页码：315 / 321

页数：7

相关论文

共 72 条

[1] TYROSYL-TRANSFER RNA-SYNTHETASE FORMS A MONONUCLEOTIDE-BINDING FOLD [J].

BHAT, TN ;

BLOW, DM ;

BRICK, P ;

NYBORG, J .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 158 (04) :699-709

[2] RNA BULGES AND THE HELICAL PERIODICITY OF DOUBLE-STRANDED-RNA [J].

BHATTACHARYYA, A ;

MURCHIE, AIH ;

LILLEY, DMJ .

NATURE, 1990, 343 (6257) :484-487

[3]

BLOW DM, 1985, NUCLEIC ACIDS INTERA, V2

[4] STRUCTURE OF TYROSYL TRANSFER-RNA SYNTHETASE REFINED AT 2.3-A RESOLUTION - INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE [J].

BRICK, P ;

BHAT, TN ;

BLOW, DM .

JOURNAL OF MOLECULAR BIOLOGY, 1989, 208 (01) :83-98

[5] CRYSTALLOGRAPHIC STUDY AT 2.5A RESOLUTION OF THE INTERACTION OF METHIONYL-TRANSFER-RNA SYNTHETASE FROM ESCHERICHIA-COLI WITH ATP [J].

BRUNIE, S ;

ZELWER, C ;

RISLER, JL .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 216 (02) :411-424

[6] UNDERSTANDING STRUCTURAL RELATIONSHIPS IN PROTEINS OF UNSOLVED 3-DIMENSIONAL STRUCTURE [J].

BURBAUM, JJ ;

STARZYK, RM ;

SCHIMMEL, P .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1990, 7 (02) :99-111

[7] IS THERE A DISCRIMINATOR SITE IN TRANSFER-RNA [J].

CROTHERS, DM ;

SENO, T ;

SOLL, DG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (10) :3063-+

[8] SEQUENCE, STRUCTURAL AND EVOLUTIONARY RELATIONSHIPS BETWEEN CLASS-2 AMINOACYL-TRANSFER RNA-SYNTHETASES [J].

CUSACK, S ;

HARTLEIN, M ;

LEBERMAN, R .

NUCLEIC ACIDS RESEARCH, 1991, 19 (13) :3489-3498

[9] A 2ND CLASS OF SYNTHETASE STRUCTURE REVEALED BY X-RAY-ANALYSIS OF ESCHERICHIA-COLI SERYL-TRANSFER RNA-SYNTHETASE AT 2.5-A [J].

CUSACK, S ;

BERTHETCOLOMINAS, C ;

HARTLEIN, M ;

NASSAR, N ;

LEBERMAN, R .

NATURE, 1990, 347 (6290) :249-255

[10] TRANSFER-RNAS - THE 2ND GENETIC-CODE [J].

DEDUVE, C .

NATURE, 1988, 333 (6169) :117-118

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