INFLUENCE OF BENIGN PROSTATIC HYPERPLASIA, TESTOSTERONE AND AGE ON SERUM LEVELS OF PROSTATE-SPECIFIC ANTIGEN

被引:6
作者
AUS, G
BERGDAHL, S
HUGOSSON, J
LODDING, P
NORLEN, L
机构
[1] Urology Division, Östra Hospital, University of Gothenburg
来源
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY | 1994年 / 28卷 / 04期
关键词
PROSTATIC NEOPLASMS; ADENOCARCINOMA; PROSTATIC HYPERPLASIA; PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE; AGE;
D O I
10.3109/00365599409180517
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Prostate specific antigen (PSA) and PSA-density (PSAd) were studied in 120 symptomatic patients with benign prostatic hyperplasia at digital rectal examination. PSA and PSAd were measured before and 3 months after transurethral resection. Comparisons were made between patients in whom histologic examination showed benign hyperplasia and those with histologically demonstrated prostatic cancer. The influence of age and of serum testosterone on PSA and PSAd was determined. PSAd in benign prostatic hyperplasia was the same in the transition zone (the adenomas) and the peripheral zone (mean 0.065), indicating no increased synthesis or leakage of PSA. PSAd with cut-off value 0.10 ng x ml(-1) cc(-1) showed higher sensitivity and positive predictive value (75% vs 50% and 0.33 vs 0.15, respectively) in nonpalpable prostatic cancer than did PSA with cut-off at 4 ng x ml(-1). No statistically significant influence of testosterone and/or age on serum-PSA or PSAd was found.
引用
收藏
页码:379 / 384
页数:6
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