AMINO-ACID SEQUENCE OF CARDIOTOXIN-ANALOGUE-2 FROM VENOM OF NAJA-NAJA-ATRA

被引：10

作者：

KANEDA, N ^{[1
]}

SASAKI, T ^{[1
]}

HAYASHI, K ^{[1
]}

机构：

[1] KYOTO UNIV, FAC PHARM SCI, DEPT BIOL CHEM, KYOTO 606, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1976年 / 72卷 / 04期

关键词：

D O I：

10.1016/S0006-291X(76)80176-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiotoxin-analogue II was isolated from the venom of N. n. atra (Formosan cobra) in a yield of 4.5% by gel filtration on Sephadex G-50 followed by CM-cellulose chromatography. When injected s.c. in mice, its LD50 was 56 .mu.g/g body weight. It was cytotoxic to Yoshida sarcoma cells [rat] and caused 50% lysis of the cells at a concentration of 7.4 .mu.g/ml. The amino acid sequence was more similar to that of cardiotoxin rather than that of cardiotoxin-analogue I from the same venom.

引用

页码：1450 / 1455

页数：6