THE EFFECT OF STRUCTURE OF MANNICH BASE PRODRUGS OF 6-MERCAPTOPURINE ON THEIR ABILITY TO DELIVER 6-MERCAPTOPURINE THROUGH HAIRLESS MOUSE SKIN

被引:8
作者
SIVER, KG [1 ]
SLOAN, KB [1 ]
机构
[1] UNIV FLORIDA,DEPT MED CHEM,BOX J-485,GAINESVILLE,FL 32610
关键词
D O I
10.1016/0378-5173(88)90264-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:195 / 206
页数:12
相关论文
共 18 条
[1]   AMINOMETHYLATION AND HYDROXYMETHYLATION OF PURINE-6(1H)-THIONE AND 6-ALKYLTHIOPURINES [J].
BRYANT, CP ;
HARMON, RE .
JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (01) :104-&
[2]   HYDROLYSIS OF N-MANNICH BASES AND ITS CONSEQUENCES FOR THE BIOLOGICAL TESTING OF SUCH AGENTS [J].
BUNDGAARD, H ;
JOHANSEN, M .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1981, 9 (01) :7-16
[3]  
Higuchi T., 1960, J SOC COSMET CHEM, V11, P85
[4]   N-MANNICH BASE DERIVATIVES OF 5-FLUOROCYTOSINE - A PRODRUG APPROACH TO IMPROVE TOPICAL DELIVERY [J].
KOCH, SAM ;
SLOAN, KB .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 35 (03) :243-252
[5]  
KRAVETZ RE, 1961, ARCH DERMATOL, V84, P113
[6]   USE OF THEORETICAL PARTITION-COEFFICIENTS DETERMINED FROM SOLUBILITY PARAMETERS TO PREDICT PERMEABILITY COEFFICIENTS FOR 5-FLUOROURACIL [J].
SHERERTZ, EF ;
SLOAN, KB ;
MCTIERNAN, RG .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 89 (02) :147-151
[7]   HYDROXYMETHYLATION AND AMINOMETHYLATION OF 6-MERCAPTOPURINE AND ITS DERIVATIVES [J].
SIVER, KG ;
SLOAN, KB ;
WARANIS, RP ;
SAAB, A .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1988, 25 (04) :1077-1081
[8]   USE OF SOLUBILITY PARAMETERS OF DRUG AND VEHICLE TO PREDICT FLUX THROUGH SKIN [J].
SLOAN, KB ;
KOCH, SAM ;
SIVER, KG ;
FLOWERS, FP .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1986, 87 (02) :244-252
[9]   HYDROXYMETHYL AND ACYLOXYMETHYL PRODRUGS OF THEOPHYLLINE - ENHANCED DELIVERY OF POLAR DRUGS THROUGH SKIN [J].
SLOAN, KB ;
BODOR, N .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1982, 12 (04) :299-313
[10]   PRODRUGS OF 6-THIOPURINES - ENHANCED DELIVERY THROUGH THE SKIN [J].
SLOAN, KB ;
HASHIDA, M ;
ALEXANDER, J ;
BODOR, N ;
HIGUCHI, T .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (04) :372-378