A HIGH-FREQUENCY OF HEPATOBILIARY DISEASE AND SUSPECTED CHOLANGIOCARCINOMA ASSOCIATED WITH HEAVY OPISTHORCHIS-VIVERRINI INFECTION IN A SMALL COMMUNITY IN NORTH-EAST THAILAND

被引：96

作者：

ELKINS, DB

HASWELLELKINS, MR

MAIRIANG, E

MAIRIANG, P

SITHITHAWORN, P

KAEWKES, S

BHUDHISAWASDI, V

UTTARAVICHIEN, T

机构：

[1] KHON KAEN UNIV,FAC MED,DEPT SURG,KHON KAEN,THAILAND

[2] KHAN KAEN UNIV,FAC MED,DEPT RADIOL,KHON KAEN,THAILAND

[3] KHAN KAEN UNIV,FAC MED,DEPT MED,KHON KAEN,THAILAND

[4] QUEENSLAND INST MED RES,TROP HLTH PROGRAM,BRISBANE,AUSTRALIA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 05期

关键词：

D O I：

10.1016/0035-9203(90)90159-C

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A group of 87 adults from a small village in north-east Thailand was chosen to undergo ultra-sound investigation based on their intensity of infection with the liver fluke, Opisthorchis viverrini, or clinical status (history of jaundice, current hepatomegaly). From this group, 8 cases of suspected early cholangiocarcinoma were found, and the diagnostic features of 6 of the 8 were confirmed by computerized tomography scan and endoscopic retrograde cholangiopancreatography. In addition, several cases of mild gall-bladder disease, chronic cholecystitis, cholelithiasis and parenchymal liver disease were detected. A highly significant positive relationship between the intensity of liver fluke worm burden and the severity of biliary tract disease within individuals is reported. These results indicate that Opisthorchis is associated with moderate to severe hepatobiliary disease in a considerable proportion of infected individuals. © 1990, Royal Society of Tropical Medicine and Hygiene. All rights reserved.

引用

页码：715 / 719

页数：5