INHIBITORY EFFECT OF GOSSYPOL ON HUMAN CHORIONIC-GONADOTROPIN (HCG)-INDUCED PROGESTERONE SECRETION IN CULTURED BOVINE LUTEAL CELLS

被引：18

作者：

GU, Y ^{[1
]}

CHANG, CJG ^{[1
]}

RIKIHISA, Y ^{[1
]}

LIN, YC ^{[1
]}

机构：

[1] OHIO STATE UNIV,COLL VET MED,DEPT VET PATHOBIOL,COLUMBUS,OH 43210

来源：

LIFE SCIENCES | 1990年 / 47卷 / 05期

关键词：

D O I：

10.1016/0024-3205(90)90298-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inhibitory effects of gossypol on the female reproductive system have been recently reported. This study investigated a possible site of gossypol action on progesterone synthesis. Bovine luteal cells were cultured with hCG and forskolin in the presence or absence of gossypol. At 10 μg/ml, gossypol significantly inhibited hCG- and forskolin-stimulated progesterone secretion and intracellular cAMP formation; at 20 μg/ml, gossypol completely abolished the stimulative effect of hCG and forskolin. The results suggest that adenylate cyclase may be a site of gossypol action on steroidogenesis of bovine luteal cells. © 1990.

引用

页码：407 / 414

页数：8

共 26 条

[1]

[Anonymous], 1978, Chin Med J (Engl), V4, P417

[2] CLINICAL-EXPERIENCE WITH GOSSYPOL IN NON-CHINESE MEN - A FOLLOW-UP [J].

COUTINHO, EM ;

MELO, JF .

CONTRACEPTION, 1988, 37 (02) :137-151

[3] INHIBITION BY GOSSYPOL OF TESTOSTERONE PRODUCTION BY MOUSE LEYDIG-CELLS INVITRO [J].

DONALDSON, A ;

SUFI, SB ;

JEFFCOATE, SL .

CONTRACEPTION, 1985, 31 (02) :165-171

[4] EFFECTS OF GOSSYPOL ON THE ESTROUS-CYCLE AND OVARIAN WEIGHT IN THE RAT [J].

GU, Y ;

ANDERSON, NO .

CONTRACEPTION, 1985, 32 (05) :491-496

[5]

HADLEY MA, 1981, J ANDROL, V2, P190

[6]

HAN ML, 1982, J COMB CHIN W MED, V2, P159

[7] GOSSYPOL AS ORAL-CONTRACEPTIVE FOR MALE - TRIAL CASE-REPORT [J].

HOSHIAI, H ;

UEHARA, S ;

MORI, R ;

NAGAIKE, F ;

TSUIKI, A ;

SUZUKI, M .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 138 (03) :275-280

[8] CYTOTOXICITY OF ENANTIOMERS OF GOSSYPOL [J].

JOSEPH, AEA ;

MATLIN, SA ;

KNOX, P .

BRITISH JOURNAL OF CANCER, 1986, 54 (03) :511-513

[9]

LIN Y C, 1984, Biology of Reproduction, V30, P103

[10] GOSSYPOL IN FEMALE FERTILITY-CONTROL - OVUM IMPLANTATION AND EARLY-PREGNANCY INHIBITED IN RATS [J].

LIN, YC ;

FUKAYA, T ;

RIKIHISA, Y ;

WALTON, A .

LIFE SCIENCES, 1985, 37 (01) :39-47

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