EFFECT OF HISTAMINE ON GASTRIC-ACID SECRETION INVITRO - INTERFERENCE WITH ENDOGENOUS PROSTAGLANDINS

被引：4

作者：

CORUZZI, G

CIABATTONI, G

ADAMI, M

BERTACCINI, G

机构：

[1] UNIV PARMA, OSPED MAGGIORE, INST PHARMACOL, VIA GRAMSCI 14, I-43100 PARMA, ITALY

[2] UNIV CATTOLICA SACRO CUORE, SCH MED, DEPT PHARMACOL, I-00168 ROME, ITALY

来源：

AGENTS AND ACTIONS | 1990年 / 30卷 / 1-2期

关键词：

D O I：

10.1007/BF01969034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interference between histamine and endogenous prostaglandins (PGs) was investigated in the isolated gastric fundus from immature rats by evaluating the effect of nonsteroidal antiinflammatory agents (NSAIDs) on the acid response to histamine and the effect of histamine on PGs production by the gastric mucosa. Indomethacin (10-5M) and diclofenac (10-5M) caused a dose-dependent enhancement of the response to histamine, dimaprit and DBcAMP, but did not affect bethanechol-, isoprenaline- and forskokin-induced acid production. The enhancing effect of indomethacin was abolished in low Ca2+ medium. PGE2 and 6-keto PGF1α levels in the mucosal solution were not modified by histamine, while being reduced by indomethacin. From these data it is concluded that endogenous PGs may negatively modulate the secretory response to histamine. However, a direct effect of the amine on cyclooxygenase to increase PGs synthesis seems to be excluded since histamine did not modify PGs levels in the mucosal solution. © 1990 Birkhäuser Verlag.

引用

页码：188 / 190

页数：3

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