INHIBITION OF HUMAN RED-BLOOD-CELL GLUTATHIONE-REDUCTASE BY VALPROIC ACID

被引：23

作者：

COTARIU, D

EVANS, S

LAHAT, E

THEITLER, J

BISTRITZER, T

ZAIDMAN, JL

机构：

[1] UNIV TEL AVIV,SACKLER FAC MED,ASSAF HAROFEH MED CTR,DEPT PEDIAT,IL,70300 ZERIFIN,ISRAEL

[2] UNIV TEL AVIV,SACKLER FAC MED,ASSAF HAROFEH MED CTR,DEPT NEUROL,IL-70300 ZERIFIN,ISRAEL

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 43卷 / 03期

关键词：

D O I：

10.1016/0006-2952(92)90559-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glutathione reductase (GR) one of the enzymes of the glutathione redox cycle, plays a salient role in maintaining appropriate cellular levels of reduced glutathione. The enzyme in human red blood cells is inhibited in vitro by the anticonvulsant drug valproic acid (VPA). The inhibition is dose-dependent, reversible, uncompetitive and does not depend on the redox state of the enzyme. VPA also inhibits red blood cell GR activity in children being treated with the drug. The level of serum VPA correlates significantly with the suppression of GR activity.

引用

页码：425 / 429

页数：5

共 9 条

[1] INTERNATIONAL COMMITTEE FOR STANDARDIZATION IN HEMATOLOGY - RECOMMENDED METHODS FOR RED-CELL ENZYME ANALYSIS [J].