USE OF FRACTAL GEOMETRY TO DETERMINE EFFECTS OF SURFACE-MORPHOLOGY ON DRUG DISSOLUTION

被引：51

作者：

FARIN, D

AVNIR, D

机构：

[1] HEBREW UNIV JERUSALEM,DEPT ORGAN CHEM,IL-91904 JERUSALEM,ISRAEL

[2] HEBREW UNIV JERUSALEM,FRITZ HABER RES CTR MOLEC DYNAM,IL-91904 JERUSALEM,ISRAEL

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1992年 / 81卷 / 01期

关键词：

D O I：

10.1002/jps.2600810111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We extend and modify the Noyes-Whitney equation and the Hixon-Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, D(R), of the effective surface which undergoes dissolution. Effects of changes in D(R) on the dissolution rate are identified and explained.

引用

页码：54 / 57

页数：4

共 51 条

[1]

AKBARIEH M, 1987, SCANNING MICROSCOPY, V1, P1397

[2]

AVNIR D, 1990, NEW J CHEM, V14, P197

[3] SURFACE GEOMETRIC IRREGULARITY OF PARTICULATE MATERIALS - THE FRACTAL APPROACH [J].