DETECTION OF THE PML/RAR-ALPHA FUSION GENE IN ACUTE PROMYELOCYTIC LEUKEMIA WITH A COMPLEX TRANSLOCATION INVOLVING CHROMOSOME-15, CHROMOSOME-17, AND CHROMOSOME-18

被引：19

作者：

OGAWA, S

MITANI, K

SATO, Y

SUGIMOTO, K

TOYOSHIMA, H

MANO, H

TAKAKU, F

YAZAKI, Y

HIRAI, H

机构：

[1] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN

[2] UNIV CALIF LOS ANGELES,SCH MED,MED CTR,DEPT PEDIAT,DIV HEMATOL ONCOL,LOS ANGELES,CA 90024

来源：

CANCER GENETICS AND CYTOGENETICS | 1993年 / 69卷 / 02期

关键词：

D O I：

10.1016/0165-4608(93)90084-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case with typical clinical features of acute promyelocytic leukemia (APL) carrying an atypical chromosomal aberration involving chromosomes 15, 17, and 18. Molecular analysis using Southern blot hybridization and reverse transcriptase-polymerase chain reaction (RT-PCR) proved the creation of the PML/RARalpha fusion gene in this case. These findings support the notion that this fusion is of crucial importance to leukemogenesis of APL.

引用

页码：113 / 117

页数：5

共 23 条

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