DETECTION OF THE PML/RAR-ALPHA FUSION GENE IN ACUTE PROMYELOCYTIC LEUKEMIA WITH A COMPLEX TRANSLOCATION INVOLVING CHROMOSOME-15, CHROMOSOME-17, AND CHROMOSOME-18

被引:19
作者
OGAWA, S
MITANI, K
SATO, Y
SUGIMOTO, K
TOYOSHIMA, H
MANO, H
TAKAKU, F
YAZAKI, Y
HIRAI, H
机构
[1] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN
[2] UNIV CALIF LOS ANGELES,SCH MED,MED CTR,DEPT PEDIAT,DIV HEMATOL ONCOL,LOS ANGELES,CA 90024
关键词
D O I
10.1016/0165-4608(93)90084-Y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We report a case with typical clinical features of acute promyelocytic leukemia (APL) carrying an atypical chromosomal aberration involving chromosomes 15, 17, and 18. Molecular analysis using Southern blot hybridization and reverse transcriptase-polymerase chain reaction (RT-PCR) proved the creation of the PML/RARalpha fusion gene in this case. These findings support the notion that this fusion is of crucial importance to leukemogenesis of APL.
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收藏
页码:113 / 117
页数:5
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