SULFUR AND THE ENEDIYNE ANTIBIOTICS

被引：4

作者：

NICOLAOU, KC ^{[1
]}

SMITH, AL ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92093 USA

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1993年 / 74卷 / 1-4期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/10426509308038100

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Some of our studies in the area of the enediyne antibiotics are discussed, with particular emphasis on the involvement of sulfur in these compounds. First, a model study for the ABC-ring system of the calicheamicin gamma1I oligosaccharide involving a [3,3]-sigmatropic rearrangement is described which enabled the stereoselective installation of the 4-thio substituent on the B-ring and which served as the cornerstone for the first synthesis of the entire oligosaccharide fragment. The first enantioselective synthesis of (-)-calicheamicinone is then described. Finally, a novel triggering device for a dynemicin mimic based upon a 2-(phenylsulfonyl)ethyl carbamate is described which led to the synthesis of an extremely potent antitumor agent.

引用

页码：47 / 58

页数：12

共 47 条

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