EFFECTS OF VASOACTIVE SUBSTANCES AND CAMP RELATED-COMPOUNDS ON ADRENOMEDULLIN PRODUCTION IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS

被引：110

作者：

SUGO, S ^{[1
]}

MINAMINO, N ^{[1
]}

SHOJI, H ^{[1
]}

KANGAWA, K ^{[1
]}

MATSUO, H ^{[1
]}

机构：

[1] NATL CARDIOVASC CTR,RES INST,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1995年 / 369卷 / 2-3期

基金：

日本科学技术振兴机构;

关键词：

ADRENOMEDULLIN; CAMP; VASOACTIVE PEPTIDE; BLOOD VESSEL; THROMBIN; RAT VASCULAR SMOOTH MUSCLE CELL;

D O I：

10.1016/0014-5793(95)00769-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To elucidate the regulation mechanism of adrenomedullin (AM) production in blood vessels, we examined the effects of 30 substances on AM production in cultured rat vascular smooth muscle cells (VSMCs). Forskolin and and 8-bromo-cAMP suppressed production and gene transcription of AM. Since VSMC expresses AM receptors coupled with adenylate cyclase, AM production may be regulated by intracellular cAMP concentration. Thrombin, vasoactive intestinal polypeptide and interferon-gamma also inhibited AM production, while angiotensin II, endothelin-1, bradykinin, substance P, adrenaline, phorbol ester and fetal calf serum stimulated AM production in VSMC. These results suggest that AM production is regulated by a variety of substances, indicating complex systems regulating AM production.

引用

页码：311 / 314

页数：4

共 23 条

[1] INTERLEUKIN-1-BETA AND TUMOR-NECROSIS-FACTOR-ALPHA SYNERGISTICALLY INDUCE NO SYNTHASE IN RAT VASCULAR SMOOTH-MUSCLE CELLS [J].