THE ACTIONS OF 2-HYDROXY-SACLOFEN AT PRESYNAPTIC GABA-B RECEPTORS IN THE RAT HIPPOCAMPUS

被引：47

作者：

HARRISON, NL

LOVINGER, DM

LAMBERT, NA

TEYLER, TJ

PRAGER, R

ONG, J

KERR, DIB

机构：

[1] NIAAA,PHYSIOL & PHARMACOL STUDIES LAB,ROCKVILLE,MD 20852

[2] NORTHEASTERN OHIO UNIV,COLL MED,DEPT NEUROBIOL,ROOTSTOWN,OH 44272

[3] FLINDERS UNIV,SCH PHYS SCI,BEDFORD PK,SA 5042,AUSTRALIA

[4] UNIV ADELAIDE,DEPT ANAESTHESIA & INTENS CARE,ADELAIDE,SA 5001,AUSTRALIA

来源：

NEUROSCIENCE LETTERS | 1990年 / 119卷 / 02期

关键词：

2-Hydroxysaclofen; GABA receptor; Hippocampus; Rat;

D O I：

10.1016/0304-3940(90)90851-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus. © 1990.

引用

页码：272 / 276

页数：5

共 31 条

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