HUMAN ALPHA-CALCITONIN GENE-RELATED PEPTIDE-(8-37) AS AN ANTAGONIST OF EXOGENOUS AND ENDOGENOUS CALCITONIN GENE-RELATED PEPTIDE

被引：97

作者：

MAGGI, CA ^{[1
]}

CHIBA, T ^{[1
]}

GIULIANI, S ^{[1
]}

机构：

[1] KOBE UNIV, SCH MED, DEPT MED, KOBE 650, JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 192卷 / 01期

关键词：

CGRP (CALCITONIN GENE-RELATED PEPTIDE); CGRP RECEPTOR ANTAGONISTS; CAPSAICIN; AFFERENTS (PRIMARY); EFFERENT FUNCTION OF SENSORY NERVES;

D O I：

10.1016/0014-2999(91)90072-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The C-terminal fragment of the human alpha-calcitonin gene-related peptide (hCGRP), hCGRP-(8-37) competitively antagonized both the positive inotropic effect of hCGRP in the guinea-pig isolated left atria (pA2 6.89) and the smooth muscle relaxant effect of hCGRP in the rat isolated vas deferens (pA2 6.55) but left the response to isoprenaline unaffected in both preparations. In addition, hCGRP-(8-37) reduced the responses produced by activation of the 'efferent' function of capsaicin-sensitive primary afferents in both preparations thus providing pharmacological evidence for the involvement of endogenous CGRP. hCGRP-(8-37) appears a useful tool to establish the physiological role of CGRP in peripheral preparations from different species.

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页码：85 / 88

页数：4

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