HIV INHIBITORY NATURAL-PRODUCTS .3. DITERPENES FROM HOMALANTHUS-ACUMINATUS AND CHRYSOBALANUS-ICACO

被引：67

作者：

GUSTAFSON, KR

MUNRO, MHG

BLUNT, JW

CARDELLINA, JH

MCMAHON, JB

GULAKOWSKI, RJ

CRAGG, GM

COX, PA

BRINEN, LS

CLARDY, J

BOYD, MR

机构：

[1] NCI, FCRDC,DEV THERAPEUT PROGRAM, DRUG DISCOVERY RES & DEV LAB,BLDG 1052,ROOM 121, FREDERICK, MD 21702 USA

[2] NCI, FCRDC, DEV THERAPEUT PROGRAM, NAT PROD BRANCH, FREDERICK, MD 21702 USA

[3] CORNELL UNIV, BAKER LAB, DEPT CHEM, ITHACA, NY 14853 USA

[4] BRIGHAM YOUNG UNIV, DEPT BOT, PROVO, UT 84601 USA

来源：

TETRAHEDRON | 1991年 / 47卷 / 26期

关键词：

D O I：

10.1016/S0040-4020(01)86461-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Extracts of the tropical rainforest trees Homalanthus acuminatus and Chrysobalanus icaco were active in the NCI AIDS-antiviral screen. Diterpenes 1-4 were found in H. acuminatus, while two (6, 7) were found in C. icaco. Compounds 1 and 6 were active in the anti-HIV screen; 1, 3 and 4 were previously unknown.

引用

页码：4547 / 4554

页数：8

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