INHIBITORS OF DNA TOPOISOMERASE-I ISOLATED FROM THE ROOTS OF ZANTHOXYLUM-NITIDUM

被引：163

作者：

FANG, SD

WANG, LK

HECHT, SM

机构：

[1] UNIV VIRGINIA, DEPT CHEM, CHARLOTTESVILLE, VA 22901 USA

[2] UNIV VIRGINIA, DEPT BIOL, CHARLOTTESVILLE, VA 22901 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 19期

关键词：

D O I：

10.1021/jo00071a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.

引用

页码：5025 / 5027

页数：3

共 60 条

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