INHIBITORS OF DNA TOPOISOMERASE-I ISOLATED FROM THE ROOTS OF ZANTHOXYLUM-NITIDUM

被引:163
作者
FANG, SD
WANG, LK
HECHT, SM
机构
[1] UNIV VIRGINIA, DEPT CHEM, CHARLOTTESVILLE, VA 22901 USA
[2] UNIV VIRGINIA, DEPT BIOL, CHARLOTTESVILLE, VA 22901 USA
关键词
D O I
10.1021/jo00071a001
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.
引用
收藏
页码:5025 / 5027
页数:3
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