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MULTIPLE TESTING IN CLINICAL-TRIALS

被引：179
作者：
BAUER, P
机构：
[1] Department of Medical Statistics, University of Cologne, Köln, D-5000
来源：
STATISTICS IN MEDICINE | 1991年 / 10卷 / 06期
关键词：
D O I：
10.1002/sim.4780100609
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The basic ideas of multiple testing are outlined and the problem of how to control the probability of erroneous decisions is discussed. The main emphasis is on the concept of the multiple level of significance (controlling the experiment, or family error in the strong sense) which can be achieved by applying the principle of closed tests. Various practical situations encountered in multiple testing in clinical trials are considered: more than one end point; more than two treatments, such as comparisons with a single control, comparisons using ordered alternatives, all pairwise comparisons and contrast methods; and more than one trial. Tests based on global statistics, the union intersection principle and other criteria are discussed. The application of the multiple test concept in sequential sampling is investigated. Finally some comments are made on multiple power, multiple confidence intervals and directed decisions.
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收藏
页码：871 / 890
页数：20
相关论文
共 78 条
  • [1] Scheffe H., A method for judging all contrasts in the analysis of variance, Biometrika, 40, pp. 87-104, (1953)
  • [2] Tukey J.W., (1952)
  • [3] Dunnett C.W., A multiple comparisons procedure for comparing several treatments with a control, Journal of the American Statistical Association, 60, pp. 573-583, (1965)
  • [4] Tippett L.M.C., The Methods of Statistics, (1931)
  • [5] Fisher R.A., Statistical Methods for Research Workers, (1932)
  • [6] Miller R.G., Simultaneous Statistical Inference, (1981)
  • [7] Spjotvoll E., On the optimality of some multiple comparison procedures, Annals of Mathematical Statistics, 48, pp. 398-411, (1972)
  • [8] Hommel G., Hoffmann T., Controlled uncertainty, Proceedings of the Symposium in Gerolstein, Multiple Hypotheses Testing, (1988)
  • [9] Ryan T.A., Multiple comparisons in psychological research, Psychological Bulletin, 56, pp. 26-47, (1959)
  • [10] Marcus R., Peritz E., Gabriel K.R., On closed testing procedures with special reference to ordered analysis of variance, Biometrika, 63, pp. 655-660, (1976)
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