MULTIPLE TESTING IN CLINICAL-TRIALS

被引：179

作者：

BAUER, P

机构：

[1] Department of Medical Statistics, University of Cologne, Köln, D-5000

来源：

STATISTICS IN MEDICINE | 1991年 / 10卷 / 06期

关键词：

D O I：

10.1002/sim.4780100609

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The basic ideas of multiple testing are outlined and the problem of how to control the probability of erroneous decisions is discussed. The main emphasis is on the concept of the multiple level of significance (controlling the experiment, or family error in the strong sense) which can be achieved by applying the principle of closed tests. Various practical situations encountered in multiple testing in clinical trials are considered: more than one end point; more than two treatments, such as comparisons with a single control, comparisons using ordered alternatives, all pairwise comparisons and contrast methods; and more than one trial. Tests based on global statistics, the union intersection principle and other criteria are discussed. The application of the multiple test concept in sequential sampling is investigated. Finally some comments are made on multiple power, multiple confidence intervals and directed decisions.

引用

页码：871 / 890

页数：20

共 78 条

[31] Lehmacher W., Wassmer G., Reitmeir P., (1988)
[32] Armitage P., McPherson C.K., Rowe B.C., Repeated significance tests on accumulating data, Journal of the Royal Statistical Society. Series A (General), 132, pp. 235-244, (1969)
[33] Pocock S.I., Group sequential methods in the design and analysis of clinical trials, Biometrika, 64, pp. 191-199, (1977)
[34] O'Brien P.C., Fleming T.R., A multiple test procedure for clinical trials, Biometrics, 35, pp. 549-555, (1979)
[35] DeMets D.L., Ware J.H., Group sequential methods in clinical trials with a one‐sided hypothesis, Biometrika, 67, pp. 651-660, (1980)
[36] Lan K.K.G., DeMets D.L., Discrete sequential boundaries for clinical trials, Biometrika, 70, pp. 659-663, (1983)
[37] Bauer P., Approximation of discrete sequential boundaries, Biometrika, 73, pp. 759-760, (1986)
[38] Bauer P., Two stage sampling for simultaneously testing main and side effects in clinical trials, Biometrical Journal, 28, pp. 871-879, (1986)
[39] Naik U.D., Some selection rules for comparing p processes with a standard, Communications in Statistics‐Theory and Methods, 4, pp. 519-535, (1975)
[40] Steel R.G.D., A multiple comparison rank sum test: treatments versus control, Biometrics, 15, pp. 560-572, (1959)

← 1 2 3 4 5 6 7 8 →