VITAMIN-D TO 1,25-DIHYDROXYCHOLECALCIFEROL - EVOLUTION OF A STEROID-HORMONE

被引：42

作者：

NORMAN, AW

HENRY, HL

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1979年 / 4卷 / 01期

关键词：

D O I：

10.1016/0968-0004(79)90239-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An endocrine system has been described which is responsible for converting the seco-steroid, vitamin D, into its hormonally active form 1,25-dihydroxy vitamin D3. Since all vitamin D steroids have a conformationally active A-ring (unlike classical steroid hormones), an intriguing biochemical problem is to evaluate how the various receptors of the vitamin D-endocrine system accommodate to these unique ligands. © 1979.

引用

收藏

页码：14 / 18

页数：5

相关论文

共 32 条

[11] PRESENCE OF RENAL 25-HYDROXYVITAMIN-D-1-HYDROXYLASE IN SPECIES OF ALL VERTEBRATE CLASSES [J].

HENRY, H ;

NORMAN, AW .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1975, 50 (NB3) :431-434

[12]

HENRY HL, 1974, J BIOL CHEM, V249, P7584

[13] STUDIES ON CALCIFEROL METABOLISM - REGULATION OF 25-HYDROXYVITAMIN D3-1-HYDROXYLASE IN ISOLATED RENAL MITOCHONDRIA [J].

HENRY, HL ;

NORMAN, AW .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1976, 172 (02) :582-589

[14]

HENRY HL, UNPUBLISHED

[15]

Hess AF, 1925, J BIOL CHEM, V64, P181

[16]

KNUTSON JC, 1974, BIOCHEMISTRY-US, V13, P1543, DOI 10.1021/bi00704a034

[17]

McCollum EV, 1922, J BIOL CHEM, V53, P293

[18]

MELANBY E, 1919, LANCET, V2, P407

[19] STUDIES ON CALCIFEROL METABOLISM .6. RENAL PRODUCTION OF BIOLOGICALLY-ACTIVE FORM OF VITAMIN-D, 1,25-DIHYDROXYCHOLECALCIFEROL - SPECIES, TISSUE AND SUBCELLULAR-DISTRIBUTION [J].

MIDGETT, RJ ;

SPIELVOGEL, AM ;

COBURN, JW ;

NORMAN, AW .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 36 (06) :1153-1161

[20] CALCIUM ABSORPTION AND CALCIUM-BINDING PROTEIN IN CHICKS ON DIFFERING CALCIUM AND PHOSPHORUS INTAKES [J].

MORRISSEY, RL ;

WASSERMAN, RH .

AMERICAN JOURNAL OF PHYSIOLOGY, 1971, 220 (05) :1509-+

← 1 2 3 4 →