KS-505A, A NOVEL INHIBITOR OF BOVINE BRAIN CA2+ AND CALMODULIN-DEPENDENT CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE FROM STREPTOMYCES-ARGENTEOLUS

被引：25

作者：

NAKANISHI, S

OSAWA, K

SAITO, Y

KAWAMOTO, I

KURODA, K

KASE, H

机构：

[1] Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Tokyo 194, 3-6-6 Asahimachi, Machida-shi

[2] Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka 411, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 03期

关键词：

D O I：

10.7164/antibiotics.45.341

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel compound, KS-505a was isolated from the culture broth of a strain identified as Streptomyces argenteolus A-2. The compound inhibited bovine brain Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase with an IC50 value (the concentration causing 50% inhibition) of 0.065-mu-M. The compound around that concentration had little or no effect on heart calmodulin-dependent and-independent cyclic-nucleotide phosphodiesterases, and protein kinase C.

引用

收藏

页码：341 / 347

页数：7

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