CONFIGURATIONAL VARIANTS OF HYDROXYPHENYLKAINOIDS - THEIR POTENT DEPOLARIZING ACTIVITIES IN THE RAT CENTRAL-NERVOUS-SYSTEM

被引：25

作者：

HASHIMOTO, K ^{[1
]}

HORIKAWA, M ^{[1
]}

ISHIDA, M ^{[1
]}

SHINOZAKI, H ^{[1
]}

SHIRAHAMA, H ^{[1
]}

机构：

[1] TOKYO METROPOLITAN INST MED SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(00)80404-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four diastereomers of 3-carboxymethyl-4-(2-hydroxyphenyl)proline were synthesized and their depolarizing activities were examined in the isolated rat spinal cord. The (2S,3S,4S)-isomer was the most potent among them, and the relationship between depolarizing activities and configurational variation was discussed.

引用

页码：743 / 746

页数：4

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