LOW BIOLOGICAL-ACTIVITY OF HELICOBACTER-PYLORI LIPOPOLYSACCHARIDE

被引：187

作者：

MUOTIALA, A

HELANDER, IM

PYHALA, L

KOSUNEN, TU

MORAN, AP

机构：

[1] NATL PUBL HLTH INST,DEPT BACTERIOL,SF-00300 HELSINKI,FINLAND

[2] NATL PUBL HLTH INST,MOLEC BIOL PROGRAM,SF-00300 HELSINKI,FINLAND

[3] NATL PUBL HLTH INST,LAB ANIM UNIT,SF-00300 HELSINKI,FINLAND

[4] UNIV HELSINKI,DEPT BACTERIOL & IMMUNOL,SF-00290 HELSINKI 29,FINLAND

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 04期

关键词：

D O I：

10.1128/IAI.60.4.1714-1716.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.

引用

页码：1714 / 1716

页数：3

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