STRUCTURE-ACTIVITY-RELATIONSHIPS OF SYNTHETIC METHYL GLYCYRRHETATE GLYCOSIDES

被引：7

作者：

TAKECHI, M

TANAKA, Y

机构：

[1] Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka

来源：

PHYTOCHEMISTRY | 1993年 / 32卷 / 05期

关键词：

STRUCTURE ACTIVITY RELATIONSHIPS; HEMOLYSIS; ANTIFUNGAL ACTIVITY; ANTIBACTERIAL ACTIVITY; SYNTHETIC GLYCOSIDES; GLYCYRRHETIC ACID; SAPONIN;

D O I：

10.1016/S0031-9422(00)95086-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Of 15 synthetic methyl glycyrrhetate glycosides, the monoglycosides having CH2OH-6 or Me-6 in their sugar moieties and the diglycosides having a (1-->4) linkage between the sugar residues showed higher haemolytic activities than the others. The beta-maltoside and beta-lactoside exhibited much stronger antifungal activities against Trichophyton mentagrophytes than the others. However, none of them exhibited antibacterial activity against Staphylococcus aureus or Bacillus subtilis.

引用

页码：1173 / 1175

页数：3

共 7 条

[1] C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].