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DIPHOSPHONATES INHIBIT FORMATION OF CALCIUM PHOSPHATE CRYSTALS IN VITRO AND PATHOLOGICAL CALCIFICATION IN VIVO

被引：552
作者：
FRANCIS, MD
RUSSELL, RGG
FLEISCH, H
机构：
[1] Miami Valley Laboratories, Procter and Gamble Company, Cincinnati
[2] Department of Pathophysiology, University of Berne
[3] Laboratory for Experimental Surgery, Davos
来源：
SCIENCE | 1969年 / 165卷 / 3899期
关键词：
D O I：
10.1126/science.165.3899.1264
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Two diphosphonates containing the P-C-P bond, CH3C(OH)(PO 3-HNa)2 and H2C(PO3HNa)2, inhibit the crystallization of calcium phosphate in vitro and prevent aortic calcification of rats given large amounts of vitamin D3. The diphosphonates therefore have effects similar to those described for compounds containing the P-O-P bond but are active when administered orally.
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页码：1264 / &
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