GENETIC-MAPPING IN THE REGION OF THE MOUSE X-INACTIVATION CENTER

被引：30

作者：

KEER, JT

HAMVAS, RMJ

BROCKDORFF, N

PAGE, D

RASTAN, S

BROWN, SDM

机构：

[1] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

[2] MRC,CLIN RES CTR,COMPARAT BIOL SECT,HARROW HA1 3UJ,MIDDX,ENGLAND

[3] MIT,WHITEHEAD INST,CAMBRIDGE,MA 02139

[4] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

GENOMICS | 1990年 / 7卷 / 04期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(90)90200-E

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mouse X-inactivation center lies just distal to the T16H breakpoint. Utilizing pedigree analysis of backcross progeny from a Mus domesticus/Mus spretus interspecific cross, we have mapped a number of genetic loci, gene probes, microclones, and EagI linking clones distal to the T16H breakpoint. The genetic analysis provides a detailed genetic map in the vicinity of the mouse X-inactivation center. Comparative mapping data from the human X chromosome indicate that the most probable location of the mouse X-inactivation center is distal to Ccg-1 and in the region of the Pgk-1 locus. We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1 Pgk-1 interval. © 1990.

引用

收藏

页码：566 / 572

页数：7

相关论文

共 32 条

[1] SPREADING OF INACTIVATION IN AN (X-14) TRANSLOCATION [J].

ALLDERDICE, PW ;

MILLER, OJ ;

MILLER, DA ;

KLINGER, HP .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1978, 2 (03) :233-240

[2] MAPPING OF THE MOUSE X-CHROMOSOME USING RANDOM GENOMIC PROBES AND AN INTERSPECIFIC MOUSE CROSS [J].

AMAR, LC ;

ARNAUD, D ;

CAMBROU, J ;

GUENET, JL ;

AVNER, PR .

EMBO JOURNAL, 1985, 4 (13B) :3695-3700

[3] CHARACTERIZATION OF A PANEL OF SOMATIC-CELL HYBRIDS FOR REGIONAL MAPPING OF THE MOUSE X-CHROMOSOME [J].

AVNER, P ;

ARNAUD, D ;

AMAR, L ;

CAMBROU, J ;

WINKING, H ;

RUSSELL, LB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (15) :5330-5334

[4] LOCALIZATION OF THE HUMAN X-LINKED GENE FOR CHRONIC GRANULOMATOUS-DISEASE TO THE MOUSE X-CHROMOSOME - IMPLICATIONS FOR X-CHROMOSOME EVOLUTION [J].

BROCKDORFF, N ;

FISHER, EMC ;

ORKIN, SH ;

LYON, MF ;

BROWN, SDM .

CYTOGENETICS AND CELL GENETICS, 1988, 48 (02) :124-125

[5] CONSTRUCTION AND ANALYSIS OF LINKING LIBRARIES FROM THE MOUSE X-CHROMOSOME [J].

BROCKDORFF, N ;

MONTAGUE, M ;

SMITH, S ;

RASTAN, S .

GENOMICS, 1990, 7 (04) :573-578

[6] THE MAPPING OF A CDNA FROM THE HUMAN X-LINKED DUCHENNE MUSCULAR-DYSTROPHY GENE TO THE MOUSE X-CHROMOSOME [J].

BROCKDORFF, N ;

CROSS, GS ;

CAVANNA, JS ;

FISHER, FMC ;

LYON, MF ;

DAVIES, KE ;

BROWN, SDM .

NATURE, 1987, 328 (6126) :166-168

[7] CONSTRUCTION OF A DETAILED MOLECULAR MAP OF THE MOUSE X-CHROMOSOME BY MICROCLONING AND INTERSPECIFIC CROSSES [J].

BROCKDORFF, N ;

FISHER, EMC ;

CAVANNA, JS ;

LYON, MF ;

BROWN, SDM .

EMBO JOURNAL, 1987, 6 (11) :3291-3297

[8] REGIONAL LOCALIZATION OF CCG1 GENE WHICH COMPLEMENTS HAMSTER-CELL CYCLE MUTATION BN462 TO XQ11-XQ13 [J].

BROWN, CJ ;

SEKIGUCHI, T ;

NISHIMOTO, T ;

WILLARD, HF .

SOMATIC CELL AND MOLECULAR GENETICS, 1989, 15 (01) :93-96

[9]

BROWN CJ, 1989, CYTOGENET CELL GENET, V51, P971

[10]

Cattanach B. M., 1989, MOUSE NEWS LETT, V83, P165

← 1 2 3 4 →