GENETIC-MAPPING IN THE REGION OF THE MOUSE X-INACTIVATION CENTER

被引：30

作者：

KEER, JT

HAMVAS, RMJ

BROCKDORFF, N

PAGE, D

RASTAN, S

BROWN, SDM

机构：

[1] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

[2] MRC,CLIN RES CTR,COMPARAT BIOL SECT,HARROW HA1 3UJ,MIDDX,ENGLAND

[3] MIT,WHITEHEAD INST,CAMBRIDGE,MA 02139

[4] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

GENOMICS | 1990年 / 7卷 / 04期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(90)90200-E

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mouse X-inactivation center lies just distal to the T16H breakpoint. Utilizing pedigree analysis of backcross progeny from a Mus domesticus/Mus spretus interspecific cross, we have mapped a number of genetic loci, gene probes, microclones, and EagI linking clones distal to the T16H breakpoint. The genetic analysis provides a detailed genetic map in the vicinity of the mouse X-inactivation center. Comparative mapping data from the human X chromosome indicate that the most probable location of the mouse X-inactivation center is distal to Ccg-1 and in the region of the Pgk-1 locus. We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1 Pgk-1 interval. © 1990.

引用

页码：566 / 572

页数：7

共 32 条

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LYON MF, 1989, MOUSE NEWS LETT, V84, P24

[22] STRUCTURAL ANOMALIES OF THE X-CHROMOSOME AND INACTIVATION CENTER [J].