BIOLOGICAL EFFECTS OF TOLYTOXIN (6-HYDROXY-7-O-METHYL-SCYTOPHYCIN-B), A POTENT BIOACTIVE METABOLITE FROM CYANOBACTERIA

被引：45

作者：

PATTERSON, GML ^{[1
]}

CARMELI, S ^{[1
]}

机构：

[1] UNIV HAWAII MANOA, DEPT CHEM, HONOLULU, HI 96822 USA

来源：

ARCHIVES OF MICROBIOLOGY | 1992年 / 157卷 / 05期

关键词：

CYANOBACTERIA; SECONDARY METABOLITE; ANTIFUNGAL; CYTOTOXIN;

D O I：

10.1007/BF00249096

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tolytoxin, a macrocyclic lactone, is a potent antifungal antibiotic, exhibiting MICs in the range of 0.25 to 8 nanomolar. Tolytoxin also inhibits the growth of a variety of mammalian cells at similar doses, without specific inhibition of macromolecular synthesis. The effects in mammalian cells are primarily cytostatic, with cell death being time- and dose-dependent. Tolytoxin is highly toxic to mice, exhibiting an LD50 (ip) of 1.5 mg/kg. No antibacterial, antiviral, or hemolytic activities were observed.

引用

页码：406 / 410

页数：5

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